miR-145: Revival of a Dragon in Pancreatic Cancer.

نویسندگان

  • Saini Setua
  • Sheema Khan
  • Kyle Doxtater
  • Murali M Yallapu
  • Meena Jaggi
  • Subhash C Chauhan
چکیده

Emergence of the role of MicroRNA-145 (miR-145) as a tumor suppressor in pancreatic cancer, offers its potential for novel therapeutic interventions. Our recently published studies demonstrate clinical significance of miR-145 in pancreatic cancer and suggest that the dysregulation of miR-145 in human pancreatic tumors draws in parallel with the aberrant expression of an oncogenic mucin, MUC13. These studies also present a novel therapeutic strategy of restoring the downregulated levels of miR-145 in pancreatic cancer via nanoparticle mediated efficient delivery system.

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عنوان ژورنال:
  • Journal of nature and science

دوره 3 3  شماره 

صفحات  -

تاریخ انتشار 2017